The job of sensing changes in nutrient concentration in the blood is performed by highly specialised cell types. Beta-cells of the pancreatic islets of Langerhans are specialized to secrete insulin when blood glucose rises. This function is particularly important: damages and/or malfunction in these cells are responsible of type 2 diabetes mellitus (T2D), one of the major causes of early mortality and morbidity over worldwide. Despite several current treatment options of type 2 diabetes, a steady decline of beta-cells function is still often observed in diabetic patients. Towards efficient amelioration of diabetes, it is required to improve beta-cells function and to stop their decline. To this end, the overall goal of the lab is aimed to better understand beta-cell function, identify signalling pathways that mediate glucose-induced insulin secretion, and to analyse their functional properties under diabetic conditions.
Two positions vacancies available
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