Proteomics in psychiatric diseases and clinically applied anatomy

Our group focuses on two lines of research. The neuroproteomics is directed on the identification of mechanisms that influence the protein composition of the nervous system under different neuropathological conditions, such as neurodegeneration or schizophrenia and is related to the proteomic service. The main goal is to identify disease specific markers and to define their role in the generation of the disease. In addition we develop new techniques, based on sample labeling with different fluorophores followed by differential two-dimensional gel electrophoresis (DIGE), thus allowing the identification of thousands of proteins of several samples on the same gel and an identification of oxidized and non-oxidized proteins either in sequential or parallel DIGE, termed redox-DIGE and oxi-DIGE. Currently we are focusing on ubiquitination and protein oxidation and sequential events in degradation/accumulation of proteins in Alzheimer's disease. The second line of research in relation to anatomical teaching activities for medical students and post graduates and focuses on clinically related research. For one, to improve  surgical procedures and to improve teaching of clinical anatomy to undergraduate students. For this, postmortem angiography is used in collaboration with legal medecine to develop teaching modules to compare anatomical structures in virtual slices and compare it to actual anatomical specimens one to one. This is to facilitate the transition from basic anatomy to applied clinical anatomy and facilitate the learning process.

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