Proteomics in psychiatric diseases and clinically applied anatomy

Our group focuses on two lines of research. The neuroproteomics is directed on the identification of mechanisms that influence the protein composition of the nervous system under different neuropathological conditions, such as neurodegeneration or schizophrenia and is related to the proteomic service. The main goal is to identify disease specific markers and to define their role in the generation of the disease. In addition we develop new techniques, based on sample labeling with different fluorophores followed by differential two-dimensional gel electrophoresis (DIGE), thus allowing the identification of thousands of proteins of several samples on the same gel and an identification of oxidized and non-oxidized proteins. Currently we are focusing on ubiquitination and protein degradation/accumulation in Alzheimer's disease. The second line of research in relation to anatomical teaching activities for medical students and post graduates and focuses on clinically related research of several surgical procedures that are tested and validated on human cadavers. Urinary and anal incontinence and prolapsus are frequent problems in elderly women, with a weak pelvic floor and diminished sphincter functions.

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